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MOLMOL is a molecular graphics program designed for display and analysis of biological macromolecules, particularly protein or DNA structures determined by nuclear magnetic resonance spectroscopy.
XREFdb is part of an attempt to identify connections between the genetics of model organisms and mammalian phenotypes.
Since its inception in 1996, Pfam has aimed to be a comprehensive database of protein families defined by the presence of shared domains.
A homolog of the tumor suppressor p53 causes damage-induced apoptosis in fruit flies.
A homolog of the tumor suppressor p53 regulates apoptosis in fruit flies.
Specific DNA targets of chromatin-associated factors have been enzymatically marked in order to identify loci that are regulated at the level of chromatin organization in eukaryotes.
Small RNAs involved in rRNA methylation and ribosome biogenesis have been found in Archaea.
Large quantities of biologically active human somatotropin have been successfully produced in plants, highlighting the promise of plant biotechnology for producing pharmaceuticals.
Systematic analysis of the chloroplast and its photosynthetic machinery has begun, using a combination of two-dimensional gels, mass spectroscopy, protein sequencing and genome databases.
A portion of the rice genome has been examined in order to evaluate the feasibility of using rice as a surrogate genome for map-based cloning of maize genes.
A comprehensive analysis has identified and localized all yeast nucleoporins in nuclear pore complexes.
A meeting report of the sessions on human, eukaryotic and bacterial genome sequencing at the American Society for Microbiology and Institut Pasteur joint conference: Genomes 2000 International Conference on Mi...
A report from the Genome Biology session of the 4th annual conference on microbial genomes, Virginia, February 12-15, 2000.
A report from the second Annual Cardiovascular Genomics Meeting, Sponsored by Cambridge Healthtech, Inc., Miami, January 31-February 1, 2000.
A report from the Keystone Protein kinase C: structure, regulation and cellular function meeting, New Mexico, February 5-10, 2000.
A report of work on the structure and function of the nuclear envelope and nuclear pores, presented at the 39th annual meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999.
Living cells organize their internal contents by coordinating the chaotic thermal motion of protein molecules. A recent study, combining experiment with stochastic simulation, shows how this might be achieved ...
Recent sequence and cytogenetic analyses of heterochromatin in Arabidopsis, together with other results from Arabidopsis and maize, indicate that plant heterochromatin can have very different origins, composition...
Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems.
The characterization of complex cellular responses to diverse stimuli can be studied by the use of emerging chip-based technologies.
Proteins of the Rab and SNARE families target vesicles to their intracellular destinations. A comparison of these families from the budding yeast, fission yeast, nematode and fruitfly genomes has implications ...
Genomic sequencing of the Toll-like receptor 4 gene in humans, mice, chimpanzee and baboon has shown that the Tlr4 protein is polymorphic.
Clever use of a mutation that allows tetrad analysis in a higher plant has enabled researchers to map the centromeres of Arabidopsis genetically with high precision.
The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individua...
On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional grou...
The use of cDNA arrays has allowed monitoring of the change in expression of host cell genes during HIV-1 infection.
Genome-wide yeast two-hybrid screening has provided a census of protein-protein interactions in Saccharomyces cerevisiae.
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