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  1. Content type: Correction

    Upon publication of the original article [1] it was highlighted by the authors that a transposition error affected Additional file 1, causing the misplacement of several columns and rendering the table difficu...

    Authors: Anthony S. Zannas, Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone Röh, Kerry J. Ressler, Charles B. Nemeroff, Alicia K. Smith, Bekh Bradley, Christine Heim, Andreas Menke, Jennifer F. Lange, Tanja Brückl, Marcus Ising, Naomi R. Wray, Angelika Erhardt…

    Citation: Genome Biology 2018 19:61

    Published on:

    The original article was published in Genome Biology 2015 16:266

  2. Content type: Meeting report

    The Annual Advances in Genome Biology and Technology (AGBT) General Meeting was held in Orlando, Florida, USA, on the 12–15 February 2018. Professors Ami S. Bhatt and Christina Curtis from Stanford University,...

    Authors: Ami S. Bhatt and Christina Curtis

    Citation: Genome Biology 2018 19:60

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  5. Content type: Method

    Recent sequencing technologies enable joint quantification of promoters and their enhancer regions, allowing inference of enhancer–promoter links. We show that current enhancer–promoter inference methods produ...

    Authors: Tom Aharon Hait, David Amar, Ron Shamir and Ran Elkon

    Citation: Genome Biology 2018 19:56

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  6. Content type: Research

    Animals can show very different behaviors even in isogenic populations, but the underlying mechanisms to generate this variability remain elusive. We use the zebrafish (Danio rerio) as a model to test the influen...

    Authors: Angel-Carlos Román, Julián Vicente-Page, Alfonso Pérez-Escudero, Jose M. Carvajal-González, Pedro M. Fernández-Salguero and Gonzalo G. de Polavieja

    Citation: Genome Biology 2018 19:55

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  9. Content type: Method

    Compared to RNA-sequencing transcript differential analysis, gene-level differential expression analysis is more robust and experimentally actionable. However, the use of gene counts for statistical analysis c...

    Authors: Lynn Yi, Harold Pimentel, Nicolas L. Bray and Lior Pachter

    Citation: Genome Biology 2018 19:53

    Published on:

  10. Content type: Research article

    Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines, ...

    Authors: Jessy Cartier, Thomas Smith, John P. Thomson, Catherine M. Rose, Batbayar Khulan, Andreas Heger, Richard R. Meehan and Amanda J. Drake

    Citation: Genome Biology 2018 19:50

    Published on:

  13. Content type: Correction

    In our recent article [1], it has come to our attention that the sample labels are not consistent between Table 1, the data labels deposited in the Sequence Read Archive, and Additional file 1: Table S2. We ar...

    Authors: Agata Wesolowska-Andersen, Jamie L. Everman, Rebecca Davidson, Cydney Rios, Rachelle Herrin, Celeste Eng, William J. Janssen, Andrew H. Liu, Sam S. Oh, Rajesh Kumar, Tasha E. Fingerlin, Jose Rodriguez-Santana, Esteban G. Burchard and Max A. Seibold

    Citation: Genome Biology 2018 19:49

    Published on:

    The original article was published in Genome Biology 2017 18:12

  14. Content type: Research

    Human pluripotent stem cells (hPSCs) provide powerful models for studying cellular differentiations and unlimited sources of cells for regenerative medicine. However, a comprehensive single-cell level differen...

    Authors: Xiaoping Han, Haide Chen, Daosheng Huang, Huidong Chen, Lijiang Fei, Chen Cheng, He Huang, Guo-Cheng Yuan and Guoji Guo

    Citation: Genome Biology 2018 19:47

    Published on:

  15. Content type: Research

    The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the interdependence of transcription initiat...

    Authors: Seyed Yahya Anvar, Guy Allard, Elizabeth Tseng, Gloria M. Sheynkman, Eleonora de Klerk, Martijn Vermaat, Raymund H. Yin, Hans E. Johansson, Yavuz Ariyurek, Johan T. den Dunnen, Stephen W. Turner and Peter A. C. ‘t Hoen

    Citation: Genome Biology 2018 19:46

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  17. Content type: Method

    3′ Untranslated regions (3' UTRs) length is regulated in relation to cellular state. To uncover key regulators of poly(A) site use in specific conditions, we have developed PAQR, a method for quantifying poly(...

    Authors: Andreas J. Gruber, Ralf Schmidt, Souvik Ghosh, Georges Martin, Andreas R. Gruber, Erik van Nimwegen and Mihaela Zavolan

    Citation: Genome Biology 2018 19:44

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  18. Content type: Research

    Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC...

    Authors: Dan Zhou, Bonnie M. Alver, Shuang Li, Ryan A. Hlady, Joyce J. Thompson, Mark A. Schroeder, Jeong-Heon Lee, Jingxin Qiu, Philip H. Schwartz, Jann N. Sarkaria and Keith D. Robertson

    Citation: Genome Biology 2018 19:43

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  20. Content type: Correction

    In the recent Research Highlight [1], it has been highlighted that part b of Fig. 1 was incorrectly labelled as “sgRNA + tracrRNA” instead of “sgRNA (crRNA + tracrRNA)”. An updated Figure 1, including also the...

    Authors: Gaetan Burgio

    Citation: Genome Biology 2018 19:41

    Published on:

    The original article was published in Genome Biology 2018 19:27

  21. Content type: Method

    Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. Here we present SUPPA2, a new method th...

    Authors: Juan L. Trincado, Juan C. Entizne, Gerald Hysenaj, Babita Singh, Miha Skalic, David J. Elliott and Eduardo Eyras

    Citation: Genome Biology 2018 19:40

    Published on:

  23. Content type: Method

    Comprehensive and accurate identification of structural variations (SVs) from next generation sequencing data remains a major challenge. We develop FusorSV, which uses a data mining approach to assess performance...

    Authors: Timothy Becker, Wan-Ping Lee, Joseph Leone, Qihui Zhu, Chengsheng Zhang, Silvia Liu, Jack Sargent, Kritika Shanker, Adam Mil-homens, Eliza Cerveira, Mallory Ryan, Jane Cha, Fabio C. P. Navarro, Timur Galeev, Mark Gerstein, Ryan E. Mills…

    Citation: Genome Biology 2018 19:38

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  24. Content type: Research

    Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexp...

    Authors: Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh…

    Citation: Genome Biology 2018 19:37

    Published on:

  25. Content type: Research

    Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic options for ovarian cancer are far from satisfactory, leading to hi...

    Authors: Linjie Zhao, Wei Wang, Shuang Huang, Zhengnan Yang, Lian Xu, Qilian Yang, Xiu Zhou, Jinjin Wang, Qiuhong Shen, Chenlu Wang, Xiaobing Le, Min Feng, Nianxin Zhou, Wayne Bond Lau, Bonnie Lau, Shaohua Yao…

    Citation: Genome Biology 2018 19:35

    Published on:

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