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A report on the 12th International Conference on Genome Informatics, Tokyo, Japan, 17-19 December 2001.
A report on the 27th Annual Lorne Conference on Protein Structure and Function, Lorne, Australia, 9-13 February 2002.
Systematic genome-wide scans to date have shown that genes of major effect are not common causes of schizophrenia, but independent linkage studies looking for schizophrenia susceptibility genes are converging ...
The anti-microbial defense system of Drosophila shows functional similarities with the vertebrate innate immune system. Two recent gene-expression profiling studies of fruitflies challenged with infectious agents...
The proteases of retroviruses, such as leukemia viruses, immunodeficiency viruses (including the human immunodeficiency virus, HIV), infectious anemia viruses, and mammary tumor viruses, form a family with the...
Big projects in biology - such as the human genome project and a number of related and ensuing enterprises - require big funding. A new tradition is growing in which some types of basic research take place wit...
The Embryo Images site provides a well-organized collection of scanning electron micrograph images of mouse embryos (with a few images of human embryos) at different stages of development.
A report on the Contemporary Concepts in Toxicology workshop 'Use of Genomic Data in Risk Assessment: State of the Art 2001' held by the Society of Toxicology, Washington DC, USA, 7-8 November 2001.
In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting genes are crucial tasks. Multivariate statistical meth...
High-density oligonucleotide arrays (HDONAs) are a powerful tool for assessing differential mRNA expression levels. To establish the statistical significance of an observed change in expression, one must take ...
The complete genome sequence of Pyrobaculum aerophilum reveals clues to how organisms can adapt to extreme temperatures
By catalyzing the joining of breaks in the phosphodiester backbone of duplex DNA, DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Three related classes of A...
Analysis of the entire genome sequence of Clostridium perfringens will help explain how gas gangrene develops in humans
A biocomputational study of the fruitfly genome reveals the presence of new genes putatively involved in fucosylation
The entire Brucella melitensis genome sequence could pave the way to a vaccine against brucellosis in humans
A Listeria monocytogenes glucose-6-phosphate translocase shows how parasitic bacteria can use molecular mimicry to survive within eukaryotic host cells
Methods for extracting useful information from the datasets produced by microarray experiments are at present of much interest. Here we present new methods for finding gene sets that are well suited for distin...
In computational analysis, the RING-finger domain is one of the most frequently detected domains in the Arabidopsis proteome. In fact, it is more abundant in Arabidopsis than in other eukaryotic genomes. However,...
Homeobox genes of the orthodenticle (otd)/Otx family have conserved roles in the embryogenesis of head and brain. Gene replacement experiments show that the Drosophila otd gene and orthologous mammalian Otx genes...
Studies of DNA repair and the maintenance of genomic integrity are essential to understanding the etiology and pathology of cancer. The availability of the complete genome sequence of Saccharomyces cerevissiae ha...
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative prot...
The E-CELL simulation environment site is dedicated to the software tool E-CELL, which simulates biochemical interactions in cells in order to understand regulation at the level of a whole cell or organelle
Large-scale microarray analyses have provided insights into the genetic control of antibiotic production by Streptomyces coelicolor
Gene-expression studies have identified two new parasite genes potentially involved in the progression of Leishmania infection in mammalian hosts
The expression of several heat-shock proteins of nitrogen-fixing bacteria is controlled post-transcriptionally by the thermosensitive secondary structure of the 'ROSE' regulatory sequences in their mRNA
Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, u...
A recent study has used serial analysis of gene expression to compare mouse forelimb and hindlimb gene-expression profiles. The method successfully identified known regulators of limb identity and has generate...
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