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Apoptosis is a physiological cell death process important for development, homeostasis and the immune defence of multicellular animals. The key effectors of apoptosis are caspases, cysteine proteases that clea...
The recent draft assembly of the human genome provides a unified basis for describing genomic structure and function. The draft is sufficiently accurate to provide useful annotation, enabling direct observatio...
A report on Novartis Foundation Symposium 244 "The Genetics and Biology of Sex Determination", London, UK, 1-3 May 2001.
The evolutionary history of eukaryotic proteins involves rapid sequence divergence, addition and deletion of domains, and fusion and fission of genes. Although the protein repertoires of distantly related spec...
Two recent reports describe mRNA and protein expression patterns in the bacterium Caulobacter crescentus. The combined use of DNA microarray and proteomic analyses provides a powerful new perspective for unraveli...
Microarrays of mouse genes are now available from several sources, and they have so far given new insights into gene expression in embryonic development, regions of the brain and during apoptosis. Microarray d...
Three types of molecular motors play an important role in the organization, dynamics and transport processes associated with the cytoskeleton. The myosin family of molecular motors move cargo on actin filament...
A report on the second European conference on zebrafish genetics and development. University College, London, 19-22 April 2001.
A report from HGM2001, the sixth annual International Human Genome Meeting organized by The Human Genome Organisation (HUGO), Edinburgh, UK, 19-22 April 2001.
The ExPASy proteomics server is a dedicated site for the analysis of protein sequences, protein structures and two-dimensional polyacrylamide gel electrophoresis.
Immotile cilia syndrome (ICS) or primary ciliary dyskinesia (PCD) is an autosomal recessive disorder in humans in which the beating of cilia and sperm flagella is impaired. Ciliated epithelial cell linings are...
The existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and, if such factors are unavailable, cells die by default...
A novel in silico method based on comparative and physicochemical considerations can help to predict the impact of amino-acid replacement on protein structure and function.
An in silico approach has been used to sort the effects on protein structure or function of amino-acid substitutions at conserved compared to non-conserved sites.
The SRY gene has been shown to be a direct transcriptional target of the WT1 transcription factor.
MacroH2A1 and macroH2A2 are two different histone loci with probable common genetic ancestry.
The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic and autoimmune diseases. Human neonata...
Techniques commonly applied to the discovery of unknown prokaryotes have now been used to identify new eukaryotic lineages within picoplankton.
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