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PAR for the course

Genome Biology20034:spotlight-20030127-01

  • Published:


  • Protein Kinase
  • Tumor Suppressor
  • Human Tumor
  • Cell Polarity
  • Germ Line

In the January 23 Nature Sophie Martin and Daniel St Johnston from the University of Cambridge, UK, show that the Drosophila LKB1 protein, a homolog of the PAR kinases identified for their role in C. elegans embryonic polarity, is required for early anterior-posterior polarity in the fly oocyte (Nature 2003, 421:379-384). They performed a genetic screen for mutants that disrupt the localization of the posterior-polarized protein Stauffen. Genome mapping led them to the lkb1 gene, which encodes a serine/threonine kinase homologous to the human tumor suppressor LKB1 and the C. elegans PAR-4 kinase that is involved in embryonic polarity. LKB1 is phosphorylated by the related PAR-1 kinase and by protein kinase A. DrosophilaLKB1 is essential for cell polarity in the germ line and the follicle cells


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  3. LKB1 - a master tumour suppressor of the small intestine and beyond.Google Scholar
  4. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.Google Scholar


© BioMed Central Ltd 2003