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The E-CELL simulation environment site is dedicated to the software tool E-CELL, which simulates biochemical interactions in cells in order to understand regulation at the level of a whole cell or organelle
Large-scale microarray analyses have provided insights into the genetic control of antibiotic production by Streptomyces coelicolor
Gene-expression studies have identified two new parasite genes potentially involved in the progression of Leishmania infection in mammalian hosts
The expression of several heat-shock proteins of nitrogen-fixing bacteria is controlled post-transcriptionally by the thermosensitive secondary structure of the 'ROSE' regulatory sequences in their mRNA
Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, u...
A recent study has used serial analysis of gene expression to compare mouse forelimb and hindlimb gene-expression profiles. The method successfully identified known regulators of limb identity and has generate...
Protein kinase C (PKC) has become a major focus among cell biologists interested in second-messenger signal transduction and much has been learned about differences in the cellular localization and function of...
The soluble glutathione transferases (GSTs, EC 2.5.1.18) are encoded by a large and diverse gene family in plants, which can be divided on the basis of sequence identity into the phi, tau, theta, zeta and lamb...
When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA...
A report on the Jackson Laboratory 'Genomics meets nanoscience' meeting, Bar Harbor, USA, 9-12 October 2001.
An erratum to The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis by AJ Furley. Genome Biology 2001, 2:reviews1026.1-1026.5
The original article was published in Genome Biology 2001 2:reviews1026.1
The fission yeast Schizosaccharomyces pombe has long been a model organism for studies of eukaryotic cells, winning renown especially for studies of the cell cycle. Now that its genome has been sequenced, S. pomb...
Genome sequence comparisons reveal that some sets of genes are in similar linkage groups in different organisms while other sets are dispersed. Are some linkage groups maintained by chance, or is there an adva...
A large-scale study of regulated gene expression has identified novel genes that may be involved in zebrafish embryonic development
A generic method for purifying protein complexes coupled with mass spectroscopic identification has enabled part of the network of interactions within the yeast proteome to be unraveled
Sites in DNA that bind regulatory proteins can be detected computationally in various ways. Pattern discovery methods analyze collections of genes suspected to be co-regulated on the evidence, for example, of ...
Concepts of orthology and paralogy are become increasingly important as whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is assumed to be conserved am...
Adenine deamination in double-stranded RNA by specific adenine deaminases efficiently blocks RNA interference in vitro
Restricting their intake of calories can further extend the lifespan of long-lived Ames dwarf mice
A report on the 'Pathogen-host cell interactions' minisymposium at the 41st Annual Meeting of the American Society for Cell Biology, Washington DC, USA, 8-12 December 2001.
The completed Arabidopsis genome seems to be of limited value as a model for maize genomics. In addition to the expansion of repetitive sequences in maize and the lack of genomic micro-colinearity, maize-specific...
Viral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identific...
Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these data remains an important challenge. A variety of tool...
For researchers interested in tumor suppressors, and in particular the p53 protein, this is a useful website; it includes a p53 database, an APC database and a p53 mutation-analysis database
Y.F. Leung's Functional Genomics website is a portal of up-to-date annotated links to databases, software, analysis materials and protocols for functional genomics, microarrays, bioinformatics, proteomics and ...
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