Fig. 1
From: Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
Types of models of RNA splicing. a SpliceAI models splicing as a black box mapping from pre-mRNA to splice sites. b We conceptualize splicing as a process in which various protein and ribonucleoprotein factors bind to the pre-mRNA sequence and influence which sites are chosen as splice sites and which are not. c Our SAM model predicts 5′ and 3′ splice site motifs and RBP binding motifs first, and then predicts which splice sites will be chosen by modeling interactions between these motifs