Fig. 10
From: ChIPr: accurate prediction of cohesin-mediated 3D genome organization from 2D chromatin features
RAD21 interactions without CTCF ChIP-Seq binding in both peaks are significantly enriched with enhancer-enhancer interactions. A, B Venn diagram showing the intersection between RAD21 interactions with CTCF binding in both peaks with those interactions with enhancer in both peaks for the GM12878 cell line (A), and simulations show that the intersection between the two sets of interactions is not significant (B). C, D Venn diagram showing the intersection between RAD21 interactions with CTCF binding in only one peak with those interactions with enhancer in both peaks for the GM12878 cell line (C), and simulations show that the intersection between the two sets of interactions is statistically significant (D). E, F Venn diagram showing the intersection between RAD21 interactions with no CTCF binding in both peaks with those interactions with enhancer in both peaks for the GM12878 cell line (E), and simulations show that the intersection between the two sets of interactions is statistically significant (F). G–L Same as A–F for the K562 cell line. ****: p-value < 0.0001, empirical test