Fig. 5
From: From beer to breadboards: yeast as a force for biological innovation
a Graphical representation of how the evolutionary conservation between orthologous human and yeast genes can be experimentally exploited to study human gene function in yeast. In this example, two variants in a human gene are shown, along with the engineered yeast ortholog (left panel). The human gene variants can be introduced, one at a time, and tested for diverse phenotypes (right panel). b A summary of the essential yeast genes for which experimental data exists for all 1:1 human orthologs