Fig. 7
From: DeepVelo: deep learning extends RNA velocity to multi-lineage systems with cell-specific kinetics
Analysis of branching dynamics in pilocytic astrocytoma (PA) tumor cells. a The DeepVelo RNA velocity results for tumor cells from the three PA samples. b The split-branch pseudotime results for the PA samples, indicating the early and late-stage tumor cells. c Upset plot showing set overlap of functionally enriched pathways, obtained from top driver genes, for branches within and across all samples. Branches are deemed “immunogenic” if they show enrichment for immune response related pathways and “depleted” otherwise. d Enrichment map of pathway enrichment analysis results for each of the two branches in the three PA samples. Each node is a pathway, colored by whether or not it was found to be statistically significantly enriched in the top 100 driver genes for each branch and sample. The size of the node indicates the size of the gene set/pathway