Fig. 3

Assess common SNP heritability enrichments for HC context-specific ELEs. For HC context-specific ELEs from each of the 105 contexts, we compute the standardized effect size (\(\tau ^\star\)) estimate and P-value for testing \(\tau ^\star >0\) conditional on all ELEs in the same context and 96 known annotations. a Estimates meta-analyzed within each of the 17 context groups (Additional file 1: Table S1) for 5 groups of related traits in EUR GWAS. Additional results are shown in Additional file 2: Fig. S3. b Estimates meta-analyzed within each of the 17 context groups for 5 traits that have both EUR and EAS GWAS available. Numerical results for a and b are available in Additional file 1: Table S9. c Estimates of 105 individual contexts for 5 exemplary traits. Numerical results are available in Additional file 1: Table S8. For a–c, each point denotes an estimate and each error bar denotes \(\pm 1.96\) SE. The color legend is provided in Additional file 2: Fig. S1j