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Fig. 4 | Genome Biology

Fig. 4

From: Structure-primed embedding on the transcription factor manifold enables transparent model architectures for gene regulatory network and latent activity inference

Fig. 4

Meta transcription factor (mTF) functional enrichment analysis in single cell yeast. mTFA estimated from hierarchical SupirFactor model trained in Fig. 3. mTFs are nodes in the SupirFactor model \(\check{\Phi }\) latent layer and are numbered from 1 to 148. A Pathway enrichment of mTFs to selected core metabolic KEGG pathway annotations on target genes. B mTF activity for cells in each growth condition (mTF activity scaled [0, 1] for comparison). C Positive (activating) and negative (repressing) weights from mTFs to target genes within the Glycolysis KEGG-pathway for each mTF. D mTF activity for cells overlaid on a low-dimensional UMAP projection. Cell metadata plotted in Additional file 1: Fig. S1

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Genome Biology

ISSN: 1474-760X

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