Fig. 6

The top positive and negative gene hits in the dasatinib survival screens were investigated at 0.25 and 0.001 FDRs. A The list of gene hits determined by the LGR and legacy libraries for the Mediator Complex (top) and Oxidative Phosphorylation pathway (bottom). The Mediator Complex has a total of 40 genes associated with the cellular component and the Oxidative Phosphorylation pathway has 162. B Line plots of the normalized sgRNA counts for the LGR unique gene hits MED8, MED12, and MED31 for the LGR (left-side panel) and legacy (right-side panel) library samples at an FDR of 0.001. The gene phenotype score determined by MAGeCK is annotated on each subplot in the upper left-hand corner