Fig. 4

Mechanisms investigation for memo-eQTLs. A Stratified four subgroups of memo-eQTLs based on the p-values of M1 models for relatively high (relH) and low (relL) subsamples of the eCpG site, 0.05 was used as the significance cutoff. B The effect size and direction of eSNPs on eGenes in eCpG relH and relL subsamples for the sigBoth memo-eQTLs. C Comparisons of the Spearman correlation coefficients for meCpG-CTCF pairs across four memo-eQTL groups (Wilcoxon rank-sum two-sided test: ns: not significant). D The number of 22Rv1 HiChIP data derived CTCF loops that overlapped with the eSNP-eCpG-eGene loci. E The illustration plot of the overlapping patterns between eSNP-eCpG-eGene loci and eCpG-CTCF loops. F The overlapping patterns between the eSNP-eCpG-eGene loci and eCpG-CTCF loops derived from 22Rv1 HiChIP data for the four memo-eQTL groups (chi-squared test: p = 1.68 × 10.⁻³)