Fig. 1
From: DNA methylation modulated genetic variant effect on gene transcriptional regulation
Correlation between meCpG and CTCF binding. A The correlation coefficients and statistical significance for the most significantly correlated meCpG and CTCF per each CTCF binding site. Neg and Pos refer to negatively correlated and positively correlated meCpG-CTCF pairs, respectively. B Examples of negatively and positively correlated meCpG-CTCF pair across 26 ENCODE samples (SCC: Spearman correlation coefficient; Pval: p-value; CpG to CTCF: the distance from the meCpG site to the center of the CTCF binding site). Comparisons of the average CpG methylation levels (C) and average CTCF binding intensity (D) between Neg and Pos groups (Wilcoxon rank-sum two-sided test: mean CpG methylation level: p < 2.20 × 10−16; mean CTCF intensity: p = 2.20 × 10−3). E Comparison of the distances between the meCpG site and the center of CTCF binding site for Neg and Pos groups (Kolmogorov–Smirnov test: p = 1.05 × 10.−5). **p < 0.01; ***p < 0.001