Fig. 6
From: Phase separation as a possible mechanism for dosage sensitivity
Phase separation predictor based on dosage-sensitive scores. A AUC performance of predicting phase-separating proteins on the test set. DosPS + represents LR predictor featuring pLI, LOEUF, pHaplo, pTriplo, SaPS, PdPS, PLAAC, PScore, catGRANULE and FuzDrop scores. B Comparison of percentage of disordered regions in proteins sets: self-assembling phase-separating (sPS) proteins, partner-dependent phase-separating (pPS) proteins and proteins with top 10% DosPS, SaPS, PdPS, PLAAC, PScore, catGRANULE score. Disordered regions were calculated with the ESpritz DisProt program. P-value was calculated with the two-sided Mann–Whitney U test. C Representative images of live U-2 OS cells transfected with EGFP tagged top-scored proteins from DosPS predictor. The white arrows indicated the existence of puncta. Scale bars, 10 μm, and 1 μm, respectively. Dots represent the protein belong to top-10%-scored proteins of corresponding predictor. D Schematic view of the dosage sensitivity model explained with phase separation