Fig. 3From: FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseasesVariants identified from massively parallel reporter assays (MPRAs) are overrepresented in top FORGEdb scores. Shown here are (A) the number of expression-modulating variants (emVars) per 1000 SNPs (divisor, y-axis) for each FORGEdb score bin (0–10) (x-axis), (B) a histogram of FORGEdb scores for emVars (orange) and 37 million SNPs available in FORGEdb (blue), (C) a histogram of FORGEdb scores for p < 0.001 MPRA variants from Kircher et al. (orange) and 37 million SNPs available in FORGEdb (blue), (D) a bar chart of FORGEdb scores (orange) and RegulomeDB (RDB) scores for p < 0.000001 emVars (blue), and (E) a bar chart of FORGEdb scores (orange) and RegulomeDB scores for p < 0.05 MPRA variants for which both a FORGEdb score and a RegulomeDB score is available from Kircher et al. (blue)Back to article page