Fig. 2

FORGEdb score (average, y-axis) versus GWAS -log10 (p-value) (x-axis) across 30 GWAS. Each colored point shows the FORGEdb score average across all GWAS SNPs at each p-value cutoff. Each grey point shows the FORGEdb score average across background SNPs (same minor allele frequency). From top left to bottom right: venous thrombosis (cor = 0.87), hair color (cor = 0.89), melanoma (cor = 0.95), colon cancer (cor = 0.77), LDL (cor = 0.81), fasting insulin (cor = 0.55), prostate cancer (cor = 0.78), diastolic blood pressure (cor = 0.82), systolic blood pressure (cor = 0.80), neutrophil cell count (cor = 0.82), eosinophil cell count (cor = 0.81), lymphocyte cell count (cor = 0.82), monocyte cell count (cor = 0.84), white blood cell count (cor = 0.83), basophil cell count (cor = 0.85), estimated glomerular filtration rate (eGFR, cor = 0.79), major depressive disorder (MDD, cor = 0.59), autism (cor = 0.96), attention deficit hyperactivity disorder (ADHD, cor = 0.89), breast cancer (cor = 0.79), lung cancer (cor = 0.90), schizophrenia (cor = 0.98), rheumatoid arthritis (cor = 0.86), Alzheimer’s disease (cor = 0.86), type 2 diabetes (cor = 0.88), inflammatory bowel disease (IBD, cor = 0.85), body mass index (cor = 0.96), red blood cell count (cor = 0.77), height (cor = 0.86), and waist-to-hip ratio (cor = 0.90)