Fig. 3
From: STmut: a framework for visualizing somatic alterations in spatial transcriptomics data of cancer
Copy number alterations are detectable in tumors profiled on the FFPE-Visium platform. Copy number alterations (CNAs) were inferred from DNA sequencing data (top heatmap) and from RNA sequencing data of individual spots (lower heatmap) in A, C, and E. Spots (rows in the lower heatmap) are ranked ordered by the similarity of their copy number profiles to the DNA copy number alterations and classified into groups (see Additional file 2: Fig. S7 for more information on groupings). An H&E stain is shown by itself and with spots overlaid for each tumor in B, D, and F. A, B A cutaneous squamous cell carcinoma adjacent to an actinic keratosis (case BB05). C, D A cutaneous squamous cell carcinoma adjacent to an actinic keratosis (case BB09). E, F A melanoma adjacent to a nevus (case patient 76)