Fig. 4
From: Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer
Roles of m3Es in CRC. A Transwell assays for HCT116 cell lines stably transfected with dCas9-KRAB sgRNAs targeting the indicated m3Es. B Representative images of transwell migration assay of HCT116 cell lines stably transfected with dCas9-KRAB m3eCBX8. Scale bar, 50um. C-F Xenograft experiments in nude mice were performed with HCT116 stable cells expressing the indicated sgRNAs. The tumors were pictured (C), and their growth curve (D), weight (E) and volume (F) are shown. n = 13 for all groups. Data are presented as mean values ± SEM. Statistical analysis was performed using a two-sided student t test. p value was labelled on the corresponding items