Fig. 2
From: Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer
The variant m3Es in CRC are enriched in genes regulating immune response. A & B Relative H3K27ac (A) and H3K4me3 (B) signals of gain m3Es in all tumor tissues. C & D Relative H3K27ac (C) and H3K4me3 (D) signals of lost m3Es in all tumor tissues. E & F Relative H3K27ac (E) and H3K4me3 (F) signals of gain typical enhancers, super enhancers and m3Es in tumor tissues. G PCA analysis using all identified significant Vm3Es classified tumor and native tissue into distinct clusters. H Human disease ontology analysis for the target genes of gain Vm3Es using GREAT (version 3.0). The pink bar represents cancer related disease and the grey bar represents other disease. I & J Representative H3K27ac (I) and H3K4me3 (J) tracks of gain m3E close to CBX8 gene. The Vm3E is highlighted in yellow