Fig. 4

Between-unit interactions. a Top: Map of the methylation sites (listed 1–45) and the five regulatory units (listed A–E) that associated with SMO expression variation. Blue: negative associations, red: positive associations. Bottom: Matrix of the correlations between the methylation levels of SMO-associated sites. Each square in the matrix shows the methylation-versus-methylation correlation (R) between two of the associated sites. Genomic coordinates of the sites are indicated to the left. Bold coordinates indicate the sites that consist the SMO expression model (see Fig. 6). The analyses of the other studied genes are given in Additional file 3. b Correlations within the entire list of methylation sites that assessed in the SMO domain. The sites and units that presented in a are indicated