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Fig. 5 | Genome Biology

Fig. 5

From: Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein

Fig. 5

Behavioral analysis of Mvp and Mapk3 genes. Selection of behavioral paradigms among 17 tested in 12 Mvp+/+;Mapk3+/+ and 12 Mvp+/−;Mapk3+/− mice, from 11 to 25 weeks of age. Elevated plus maze (A). Open field (B). Fear conditioning (C). Tail suspension (D). PTZ test (E). Forced swim (F). G Summary table of core functions assessed in various cohorts. Green indicates significance, gray no difference, and white indicates not done (not d.). Arrows indicate the directionality of the effect, and the equal signs indicate no changes. A comprehensive description of behavioral tests, raw datasets, and additional findings are provided in Additional file 9, Additional file 6: Tables S10, Additional file 7: Tables S11, Additional file 8: Tables S12, and Additional file 1: Figs. S10-S12, respectively. The mean and standard error of the mean are shown in the graphs. Two-tailed Student t test equal variance (A, DF) and two-way ANOVA with Sidak post hoc (B, C). *p < 0.05, **p < 0.01, ***p < 0.001

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