Fig. 4
From: Landscape of enhancer disruption and functional screen in melanoma cells
Target genes analysis of melanoma functional enhancers based on H3K27ac HiChIP. a Candidate target genes of the top 20 functional enhancers, genes are labeled with different colors according to different evidence sources. b KEGG pathway enrichment analysis of the target genes with cancer-related evidence. c Target gene distribution in public A375 CRISPR KO positive screen, significant target genes for the top 20 functional enhancers are labeled. d Target gene distribution in the differential expression analysis of TCGA-SKCM samples, significant target genes for the top 20 functional enhancers are labeled. e Overlaps among target genes of the functional enhancers, A375 CRISPR KO positive selected genes and significantly downregulated genes in TCGA-SKCM. f Overlaps among target genes of the functional enhancers and different layers of tumor suppressor evidence