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Fig. 4 | Genome Biology

Fig. 4

From: Performance of computational algorithms to deconvolve heterogeneous bulk ovarian tumor tissue depends on experimental factors

Fig. 4

Method of mRNA enrichment affects gene expression profile. A A principal component analysis of the rRNA- Dissociated and polyA+ Dissociated bulk samples, where color indicates patient of origin and shape indicates whether samples were poly-A captured or rRNA depleted. Two points that are close together on the PCA plot are similar in their expression profiles. B A volcano plot of the differential expression results based on mRNA enrichment method, with gene sets of interest colored: histones, other non-polyadenylated genes [53], and mitochondrial genes. C Combined expression of all histone genes in each sample based on mRNA enrichment method. D Combined expression of all mtDNA genes based on mRNA enrichment method

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Genome Biology

ISSN: 1474-760X

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