Fig. 1
From: Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet
C/EBPβ (GSM915179 [55]; 11 434 ChIP-seq peaks) CentriMo analysis of de novo and JASPAR motifs (Methods). Depicts female replicate 2 of the combined WGBS and oxWGBS data [51] at a 0.3 modification threshold. A The CentriMo result with the JASPAR C/EBPβ motif (orange), top Discriminative Regular Expression Motif Elicitation (DREME) unmethylated C/EBPβ motif (blue), and DREME methylated motifs (red, cyan, and green). B Sequence logo of the JASPAR C/EBPβ motif. C Sequence logo of the top DREME unmodified motif. D Sequence logo of the top DREME methylated motif. E Sequence logo of the second DREME methylated motif. F Sequence logo of the third DREME methylated motif. Listed p-values computed by CentriMo [56]. For consistency, we depict the JASPAR sequence logo using MEME’s relative entropy calculation and colouring