Fig. 7

Additive cis and trans-eQTLs at the hotspot chr10:85 Mb-86 Mb in HS rat heart. a Independent additive cis-eQTLs within the hotspot, Nfe2l1. b–d Manhattan plots for genes Gzmb, Cd160, and F1lnm2 with partial-dominant trans-eQTL mapping to Nfe2l1. Within each Manhattan plot, the eQTL is marked by a dotted rectangular frame, with the same color as the peak SNP dot (blue—additive; sky blue—partial-dominant; purple—complete-dominant; red—over-dominant), and all linked SNPs with − log10(P) > 0.5 are colored likewise. The regional Manhattan plots of the peak signal of each eQTL and the scatter plots of two cis-eQTLs are also shown as insets. The pairs of scatter plots to the right of each Manhattan plot compare the expression of each gene with Nfe2l1 (nearby over-dominant cis-eQTL), showing how these nearby genes are correlated with independent sets of trans-eQTLs. Each dot represents one animal, color-coded by the genotype of the peak SNP