Table 3 Univariate and multivariate analyses for clinical characteristics of EFS and OS in adult AML patients

Age > 60

1.93 (1.18–3.17)

0.009^***

2.24 (1.32–3.81)

0.003^***

1.45 (0.846–2.47)

0.178

1.58 (0.883–2.82)

0.124

BM blast > 70%

1.54 (0.804–2.96)

0.192

1.48 (0.747–2.94)

0.260

CD69⁺ HSC-like% (high vs low)

2.47 (1.5–4.07)

0.000^***

2.36 (1.39–4.02)

0.001^***

1.85 (1.04–3.27)

0.035^**

2.1 (1.17–3.76)

0.013^**

LSC score (high vs low)

2.87 (1.72–4.81)

0.000^***

2.47 (1.44–4.23)

0.001^***

2.5 (1.34–4.66)

0.004^***

2.11 (1.12–3.98)

0.021^**

Gender (male vs female)

0.988 (0.604–1.62)

0.962

0.943 (0.56–1.59)

0.824

Cytogenetic Risk Favorable

0.606 (0.261–1.41)

0.243

0.514 (0.205–1.29)

0.157

Cytogenetic Risk Intermediate/Normal

1.1 (0.648–1.88)

0.719

1.22 (0.689–2.16)

0.495

Cytogenetic Risk Poor

1.21 (0.668–2.2)

0.529

1.18 (0.624–2.25)

0.606

Molecular Risk Good

0.606 (0.261–1.41)

0.243

0.514 (0.205–1.29)

0.157

Molecular Risk Intermediate

0.958 (0.575–1.6)

0.870

0.833 (0.486–1.43)

0.504

Molecular Risk Poor

1.39 (0.806–2.41)

0.234

1.87 (1.05–3.33)

0.033^**

1.13 (0.625–2.04)

0.689

1.88 (1.01–3.47)

0.045^**

cytogenetic BCR-ABL1

12.9 (2.75–60.1)

0.001^***

1.73 (0.237–12.7)

0.588

cytogenetic CBFB-MYH11

0.847 (0.307–2.34)

0.749

0.603 (0.188–1.94)

0.395

cytogenetic Complex

1.1 (0.439–2.74)

0.844

1.6 (0.636–4.02)

0.318

cytogenetic Intermediate Risk Abnormality

1.56 (0.788–3.1)

0.201

1.52 (0.741–3.13)

0.252

cytogenetic MLL, poor risk

0.826 (0.202–3.38)

0.791

1.03 (0.25–4.23)

0.969

cytogenetic MLL, t(9;11)

2.55 (0.345–18.8)

0.360

4.01 (0.533–30.1)

0.177

cytogenetic Normal

0.843 (0.514–1.38)

0.497

0.798 (0.471–1.35)

0.399

cytogenetic Poor Risk Abnormality

1.13 (0.407–3.11)

0.819

1.57 (0.564–4.34)

0.389

cytogenetic RUNX1-RUNX1T1

0.41 (0.1–1.68)

0.215

0.463 (0.113–1.9)

0.285

FLT3-ITD

1.41 (0.828–2.4)

0.206

1.12 (0.628–2.01)

0.693

FLT3-PM

2.05 (0.929–4.53)

0.075^*

2.71 (1.2–6.08)

0.016^**

CEBPA mutation

0.663 (0.241–1.83)

0.427

0.708 (0.256–1.96)

0.507

DNMT3A/B mutation

1.54 (0.898–2.64)

0.117

2.13 (1.22–3.74)

0.008^***

NPM1 mutation

0.839 (0.503–1.4)

0.502

0.765 (0.443–1.32)

0.336

RUNX1 mutation

1.39 (0.552–3.51)

0.484

1.89 (0.742–4.84)

0.181

TP53 mutation

2.34 (0.846–6.47)

0.101

3.62 (1.29–10.2)

0.015^**

WT1 mutation

0.988 (0.45–2.17)

0.977

0.733 (0.314–1.71)

0.474

SCT

0.642 (0.392–1.05)

0.078^*

0.483 (0.284–0.822)

0.007^***

0.497 (0.282–0.874)

0.015^**

0.353 (0.19–0.657)

0.001^***