Fig. 2
From: PhyloMed: a phylogeny-based test of mediation effect in microbiome
Quantile-quantile plots of p-values from different global mediation tests in the simulation study for the continuous outcome. The observed p-values were compared to the expected quantiles generated by the uniform null distribution. The \(|\mathcal {S}_\alpha |\) and \(|\mathcal {S}_\beta |\) denote the number of treatment-associated OTUs and outcome-associated OTUs, respectively. Different combinations of (\(|\mathcal {S}_\alpha |\), \(|\mathcal {S}_\beta |\)) represent different mixtures of mediation nulls \(H_{00}\), \(H_{10}\), and \(H_{01}\)