Fig. 5
From: Multi-omics analysis identifies drivers of protein phosphorylation
Phosphopeptide abundance can be regulated by both substrate abundance dependent and non-substrate abundance dependent mechanisms. A COMT pQTL and phQTL for COMT were mapped to different loci in liver tissue. B A local CAST allele at Comt drove high abundance of COMT in liver tissue. C Adjusted abundance of COMT pS261 categorized according to founder haplotype at Cdc14b. D Mediation analysis using transcriptomics data identified Cdc14b as the mediator of a phQTL for COMT pS261. Each gray dot is a mediation score representing the COMT pS261 phQTL LOD score conditioned on a transcript as candidate mediator. E Abundance of Cdc14b transcripts pS261 categorized according to founder haplotype at Cdc14b. The abundance of COMT pS261 is less correlated with Cdc14b transcripts before adjustment (r = −0.49) (F) compared to after adjustment (G) (r = −0.62). H Path diagram of COMT pS261 abundance regulation in liver tissue