Fig. 3
Maintenance, loss, and gain of LADs in the first 24 h of adipogenic differentiation. a Definition of lost/gain LADs and LAD edges. b Proportions of common LADs (center), gained/lost LADs, and gained/lost LAD edges between T00 and T24 (mb coverage). c Violin and box plot of LAD size distribution per LAD category; box plot: dot, median; box: 25–75% percentile; whiskers, min-max. d LMNB1 and e H3K9me3 enrichment in each LAD category and i-LADs in the 0–24-h time course; ****P < 10−4, and §P < 10−4 relative to all LAD category; ANOVA with Welch’s correction. f Genome browser views of Log2(ChIP/input) ratios for LMNB1 and H3K9me3 (y axis range shown in brackets) in vLADs (red boxes) and cLADs (blue boxes). g Fold-change of expression of DE genes between 0 and 24 h in each T00–T24 LAD category; bar, median; cross, mean; box, 25–75% percentile; whiskers, min-max; dots, data points. **P = 0.002 (one-sample t-tests)