Fig. 5
From: PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
An atlas of optimized PRSs for complex diseases and traits. 45 diseases/traits with optimized R2 > 0.005 are included in the figure. Each circle represents a disease or trait. The size of circles indicates the sample size of the study; colors mark the five trait categories. The X-axis indicates the negative log-transformed p-value cutoff in PRS which is also the tuning parameter of interest. The Y-axis indicates the optimal R2. Information on all diseases and traits is summarized in Additional file 7: Table. S6