Fig. 4
From: PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
Technical issues involving sample size and LD clumping. A PUMAS results on LDL cholesterol and EA with various sample size specifications. The two gray dashed lines represent the optimal p-value cutoffs selected by the “QCed” setting for LDL and EA, respectively. B Predictive performance on external validation for AD PRS based on pruned and clumped summary statistics. Two gray dashed lines mark the optimal p-value cutoffs inferred by PUMAS on pruned and clumped summary statistics. LDL low-density lipoprotein, EA educational attainment, AD Alzheimer’s disease