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Fig. 1 | Genome Biology

Fig. 1

From: scDesign2: a transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured

Fig. 1

An overview of scDesign2. The input for scDesign2 is a gene-by-cell count matrix with cells labeled as cell types or clusters. For cells in each type or cluster, scDesign2 uses the copula framework to fit a joint distribution of gene expression counts. Then, given user-specified sequencing depth and number of cells, scDesign2 generates synthetic data for each cell type or cluster. The synthetic data can be used to guide experimental design and evaluate computational methods

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Genome Biology

ISSN: 1474-760X

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