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Fig. 5 | Genome Biology

Fig. 5

From: Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus

Fig. 5

Autoantibodies in patients with the DAP1 risk haplotype. a Distribution of ANA in SLE patients with three different genotypes of the rs2930047 SNP. b Average normalized fluorescent intensity (NFI) for 89 autoantigens (IgG) in SLE patients with three different genotypes of the rs2930047 SNP. c Enrichment of specific autoantibodies in DAP1 SLE risk haplotype compared to the protective haplotype. d Enrichment of specific autoantibodies and clinical phenotypes in DAP1 SLE risk haplotype compared to the protective haplotype. In this independent set of samples, SLE patients with risk allele showed higher odds for clinical phenotypes such as oral ulcers, discoid rash and sm, and RNP antibodies. e Enrichment of sm/smD antibodies in DAP1 SLE risk haplotype compared to the protective haplotype in a cohort of apparently healthy subjects that carried DAP1 risk (n = 9) or protective (n = 8) genotype

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Genome Biology

ISSN: 1474-760X

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