Skip to main content
Fig. 3 | Genome Biology

Fig. 3

From: Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

Fig. 3

DNA methylation similarity between primary tumors and paired metastases. a Unsupervised clustering of all samples including normal tissues based on DNA methylation level of all CpG islands (n = 27,000). b Correlation of promoter DNA methylation between primary tumors and metastases for the 1084 genes showing a negative correlation between DNA methylation and gene expression (Spearman’s rank correlation ≤ − 0.5 based on the data in our main cohort). c Correlation of promoter DNA methylation level between primary tumors and metastases for the 521 genes previously reported to be regulated by DNA methylation in NSCLC from the study examining 73 cell lines

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us