Fig. 3
From: CRISPR and transposon in vivo screens for cancer drivers and therapeutic targets
Applications of CRISPR and transposon mutagenesis for in vivo cancer screens. Cancer is typically genetically and phenotypically heterogeneous, and immune cells in the microenvironment play a pivotal role in oncogenesis. Key areas for investigation of cancer by in vivo screens include genetic mechanisms of tumor heterogeneity, metastasis, immune evasion, and resistance to treatment. “T” = transposon mutagenesis; “C” = CRISPR