Fig. 2
HBA-DEALS evaluation. a Precision-recall (PR) analysis of HBA-DEALS and five state-of-the-art algorithms for the detection of RNA-seq differential expression. b PR analysis of HBA-DEALS, OSTP, and rMATS. In panels a and b, the Y axis shows precision and the X axis shows 1-recall. cR2 for gene expression (GTEx, distant). Data points shown in color represent correlations based on genes that were identified as differentially expressed by HBA-DEALS. As a control, genes not identified as differentially expressed with probability p≥0.25, see the “Methods” section) are shown in gray (abbreviations in Additional file 1: Table S2). dR2 for isoform proportion (GTEx, distant). Data points shown in color represent correlations based on isoforms identified as differentially spliced by HBA-DEALS. As a control, isoforms from genes not identified as differentially spliced (p≥0.25) are shown in gray