Fig. 5

Summary of DFI results. a Distribution (%) of features annotated in the transcriptome (dots) vs differentially included features revealed by the analysis (bars). The relative over-representation of DFI features in specific categories is evaluated by Fisher exact tests and corrected for multiple testing using the Benjamini-Hochberg method. b Distribution (%) of differentially included features according to the cell type in which the inclusion of the feature is favored. Enrichment of the feature category in the cell type is calculated by a binomial test with probability = 0.5 and Benjamini-Hochberg multiple testing correction. c Barplot of feature inclusion differences (ΔFI) across feature category. For all DFI results, the significance of individual categories (see the “Methods” section) is marked by asterisks: ***p < 0.001; **p < 0.01; *p < 0.05. d Top 15 co-DFI associations ranked by the number of genes with both features marked as DFI. Bar color indicates the number of genes where features are co-included in the same conditions (co-inclusion) or in opposite conditions/groups (mutual exclusion)