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Table 1 Genomic interaction dataset

From: A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods

Assay

Reference

3D chromatin interactions

 Hi-C

High-resolution in situ Hi-C: identifies chromatin loops anchored by convergent CTCF binding sites

[14]

 RNAPII ChIA-PET

Chromatin interaction analysis by paired-end tag sequencing targeting RNAPII: identifies chromatin interactions enriched for RNAPII binding

[16]

 CTCF ChIA-PET

Chromatin interaction analysis by paired-end tag sequencing targeting CTCF: identifies chromatin interactions enriched for CTCF binding

[16]

 CHi-C

Promoter capture Hi-C: identifies chromatin interactions between promoters and other loci

[17]

Genetic interactions

 eQTLs

Expression quantitative trait loci: identifies genetic variants correlated with changes of gene expression of individuals in a human population

[18, 19]

CRISPR/Cas9 perturbations

 crisprQTLs

Identifies loci that when targeted with CRISPR/Cas9 correlate with changes in gene expression measured in single cells

[20]