Fig. 2

Lineage-specific drug sensitivity among gynecologic tumors. a Volcano plot representation of gynecologic tumor type-specific drug response, with fold-change drug comparison (x-axis) and its significance (y-axis). Each circle represents a single tumor type-drug interaction, and the size is proportional to the cohort size of the respective tumor. b Heatmap representation of plot A. Only significant associations have been marked based on sensitivity (red) or resistance (blue). Drugs have been clustered based on their known target classes. c Violin plots demonstrating the pathway enrichment scores of each corresponding pathway. The activity scores were measured using single sample Gene Set Enrichment Analysis (ssGSEA). Horizontal lines within the violin plots represent 0.25, 0.50, and 0.75 quantiles. P values in a–c: two-sided Wilcoxon’s rank-sum test