Fig. 2
From: Illuminating the genome-wide activity of genome editors for safe and effective therapeutics
Functional classification of sites of off-target genome-editing mutations. A proposed framework outlining principles for defining the function of sites of off-target mutation. Some sites should be strictly avoided (red), others may require caution in interpretation (yellow), and a few in isolated topologically associated domains (TADs) may be non-functional and unlikely to be deleterious (green)