Fig. 6
From: Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation
Model for the different patterns of stimulus-induced histone modifications. (i) Stimulation induces the binding of primary TFs and their interacting histone modifiers (orange) at regions pre-defined by lineage-defining TFs (gray), leading to early increases in histone modifications. (ii) Secondary regulators, Pol2, and interacting histone modifiers (green) establish additional modifications at specific time points. (iii) Downstream regulators and existing histone modifications lead to further recruitment of histone modifiers (purple), establishing a stably active chromatin state