From: Experimental design and quantitative analysis of microbial community multiomics
Tool
Infers directed interaction?
Adjusts for covariates?
Reference(s)
CCREPE/ReBoot
No
[64]
SparCC
[65]
CCLasso
[66]
REBACCA
[139]
SPIEC-EASI
[67]
MENAP
[140]
MInt
Yes
[141]
MetaMIS
[142]
BioMiCo/BiomeNet
[143, 144]
MDSINE
[87]
DBN
[145]