Fig. 1
From: Evaluation of in silico algorithms for use with ACMG/AMP clinical variant interpretation guidelines
Concordance among predictions of 18 algorithms for variants in ClinVar. Binary predictions made by 18 algorithms for each pathogenic or benign variants in ClinVar are shown in the upper and lower panels. Each variant is along a row and an orange, green, or white tile depicts a pathogenic, benign, or missing data call, respectively, by the corresponding algorithm. A total of 14,819 variants with ClinVar review status one star or above (a) and 2966 variants with ClinVar review status two stars or above (b) are shown