Fig. 2From: A statistical framework for analyzing deep mutational scanning dataWild-type frequency can change non-linearly. The change in frequency of the wild-type over the course of replicate selections is shown for (a) BRCA1 E3 ubiquitin ligase, (b) BRCA1-BARD1 binding, or (c) E4B E3 ubiquitin ligase. Each colored line represents a single replicateBack to article page