Fig. 4
From: MeDeCom: discovery and quantification of latent components of heterogeneous methylomes
Results for brain methylomes. a–d Decomposition of the FC1 data set. a Selection of parameters k and λ by cross-validation. b Matching frontal cortex LMCs to the reference NeuN +/− profiles. The dendrogram visualizes agglomerative hierarchical clustering analysis with a correlation-based distance measure and average linkage. c Matching of LMCs between FC1 and FC2. d Example of an LMC1-specific CpG (k=3) in the PAX6 locus. e, f AD-associated LMCs in the FC2 data set. e LMC2 is associated with the AD phenotype (Wilcoxon rank sum test P=3.1×10−4). f LMC2 is also significantly associated with the Braak stage (P=4.8×10−3, T test of the linear regression coefficient). g Clustering of the recovered LMCs for k=9 with the LMCs for k=3 and reference profiles. LMC2 belongs to the NeuN −-associated cluster. h Most significant gene ontology terms from the biological process category for the LMC2-associated hypermethylated genes