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Fig. 4 | Genome Biology

Fig. 4

From: Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery

Fig. 4

Graphical representation of the M30 co-expression and protein-protein interaction network and its relationship to epilepsy. Genes in M30 impacted by single nucleotide variant non-synonymous DNM from epileptic encephalopathy (EE) cases are filled in light red. The bold border of circles indicates genes showing nominal association with susceptibility by GWAS to generalised epilepsy (GGE) and/or to focal epilepsy (FE) using a yellow to red gradient colour according to the minimal P value. Genes disrupted by non-synonymous DNMs in EE patients are enriched in genes coding for proteins with higher number of intra-modular PPI (GSEA ranking genes according to the number of intra-modular PPI, NES: 2.4, FDR q-value: 0.0013; FET testing the enrichment of DNMs among genes coding for proteins with more than two intra-modular PPI: P value = 4.245 × 10–4, OR = 6.77)

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Genome Biology

ISSN: 1474-760X

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