Fig. 1

Overview of MUFFINN. a While conventional methods based on mutation data prioritize genes with mutation frequency only, MUFFINN prioritizes genes based on the mutation frequency of each gene as well as that of its neighbors in a functional network. Various network algorithms incorporate mutational information of network neighbors: b mutation frequency of direct neighbor genes of maximum mutation frequency; c mutation frequency of all direct neighbors with normalization by the number of their network neighbors; and d mutational frequency of all genes of the entire network with diffused weight through the network