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Table 1 Patient-specific expression of cytokine and receptor genes by tumor cells complementing the signaling networks constructed in Figs. 4 and 6

From: A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome

Gene

Description

Min. TPM

Max. TPM

Cytokines

  BMP8B

Bone morphogenetic protein 8b

0.32

32.17

  CXCL6

Chemokine (C-X-C motif) ligand 6

0.00

7.74

  CXCL14

Chemokine (C-X-C motif) ligand 14

0.00

5.74

  DKK1

Dickkopf WNT signaling pathway inhibitor 1

0.00

7.49

  EFNA3

Ephrin-A3

0.95

16.74

  EGF

Epidermal growth factor

0.09

10.16

  FGF2

Fibroblast growth factor 2 (basic)

0.02

29.35

  FGF9

Fibroblast growth factor 9

0.08

15.31

  FGF11

Fibroblast growth factor 11

0.48

6.17

  FGF13

Fibroblast growth factor 13

0.08

9.04

  FGFBP1

Fibroblast growth factor binding protein 1

0.00

28.97

  KITLG

KIT ligand

0.04

7.48

  NDP

Norrin (Norrie disease pseudoglioma)

0.00

5.44

  NRG1

Neuregulin 1

0.02

5.23

  NRG2

Neuregulin 2

0.04

4.59

  NRG3

Neuregulin 3

0.00

13.39

  PDGFD

Platelet derived growth factor D

0.29

6.58

  RSPO3

R-spondin 3

0.02

8.90

  S100A7

S100 calcium binding protein A7

0.00

4.03

  S100P

S100 calcium binding protein P

0.00

12.00

  SEMA3D

Semaphorin 3D

0.00

6.07

  SEMA3E

Semaphorin 3E

0.13

93.32

  SEMA4G

Semaphorin 4G

0.16

6.74

  SEMA5B

Semaphorin 5B

0.03

19.94

  SEMA6C

Semaphorin 6C

0.68

4.76

  SEMA7A

Semaphorin 7A

0.26

9.55

  SFRP1

Secreted frizzled-related protein 1

0.00

527.58

  TGFB3

Transforming growth factor, beta 3

0.07

4.51

Cytokine receptors

  AGER

Advanced glycosylation end product receptor

0.30

5.01

  EPHA6

EPH receptor A6

0.13

25.52

  FGFR4

Fibroblast growth factor receptor 4

0.33

3.76

  FZD2

Frizzled family receptor 2

0.22

6.18

  FZD10

Frizzled family receptor 10

0.00

7.95

  IL10RA

Interleukin 10 receptor, alpha

0.00

5.91

Lipid mediators

  ALOX15B

Arachidonate 15-lipoxygenase, type B

0.06

8.03

Lipid receptors

  LTB4R2

Leukotriene B4 receptor 2

1.11

3.78

  PTGER3

Prostaglandin E receptor 3 (subtype EP3)

0.10

11.87